A Stressed-out Childhood Could Seriously Ruin Your Kid’s Brain

Mladenoff Clinic AZ • July 21, 2018

ASHEVILLE, N.C. — A quiet, unsmiling little girl with big brown eyes crawls inside a carpeted cubicle, hugs a stuffed teddy bear tight, and turns her head away from the noisy classroom.

The safe spaces, quiet times and breathing exercises for her and the other preschoolers at the Verner Center for Early Learning are designed to help kids cope with intense stress so they can learn. But experts hope there’s an even bigger benefit — protecting young bodies and brains from stress so persistent that it becomes toxic.

It’s no secret that growing up in tough circumstances can be hard on kids and lead to behavior and learning problems. But researchers are discovering something different. Many believe that ongoing stress during early childhood — from grinding poverty, neglect, parents’ substance abuse and other adversity — can smolder beneath the skin, harming kids’ brains and other body systems. And research suggests that can lead to some of the major causes of death and disease in adulthood, including heart attacks and diabetes.

“The damage that happens to kids from the infectious disease of toxic stress is as severe as the damage from meningitis or polio or pertussis,” says Dr. Tina Hahn, a pediatrician in rural Caro, Michigan. She says her No. 1 goal as a physician is to prevent toxic stress. Hahn routinely questions families about stresses at home, educates them about the risks and helps them find ways to manage.

Mounting research on potential biological dangers of toxic stress is prompting a new public health approach to identifying and treating the effects of poverty, neglect, abuse and other adversity. While some in the medical community dispute that research, pediatricians, mental health specialists, educators and community leaders are increasingly adopting what is called “trauma-informed” care.

The approach starts with the premise that extreme stress or trauma can cause brain changes that may interfere with learning, explain troubling behavior, and endanger health. The goal is to identify affected children and families and provide services to treat or prevent continued stress. This can include parenting classes, addiction treatment for parents, school and police-based programs and psychotherapy.

Many preschoolers who mental health specialist Laura Martin works with at the Verner Center have been in and out of foster homes or they live with parents struggling to make ends meet or dealing with drug and alcohol problems, depression or domestic violence.

They come to school in “fight or flight” mode, unfocused and withdrawn or aggressive, sometimes kicking and screaming at their classmates. Instead of adding to that stress with aggressive discipline, the goal is to take stress away.

“We know that if they don’t feel safe then they can’t learn,” Martin said. By creating a safe space, one goal of programs like Verner’s is to make kids’ bodies more resilient to biological damage from toxic stress, she said.

Many of these kids “never know what’s going to come next” at home. But at school, square cards taped at kids’ eye level remind them in words and pictures that lunch is followed by quiet time, then a snack, then hand-washing and a nap. Breathing exercises have kids roar like a lion or hiss like a snake to calm them. A peace table helps angry kids work out conflicts with their classmates.

‘We know that if they don’t feel safe then they can’t learn’

- Laura Martin

The brain and disease-fighting immune system are not fully formed at birth and are potentially vulnerable to damage from childhood adversity, recent studies have shown. The first three years are thought to be the most critical, and children lacking nurturing parents or other close relatives to help them cope with adversity are most at risk.

Under normal stress situations — for a young child that could be getting a shot or hearing a loud thunderstorm — the stress response kicks in, briefly raising heart rate and levels of cortisol and other stress hormones. When stress is severe and ongoing, those levels may remain elevated, putting kids in a persistent “fight or flight” mode, said Harvard University neuroscientist Charles Nelson.

Recent studies suggest that kind of stress changes the body’s metabolism and contributes to internal inflammation, which can raise risk for developing diabetes and heart disease. In 2015, Brown University researchers reported finding elevated levels of inflammatory markers in saliva of children who had experienced abuse or other adversity.

Experiments in animals and humans also suggest persistent stress may alter brain structure in regions affecting emotions and regulating behavior. Nelson and others have done imaging studies showing these regions are smaller than usual in severely traumatized children.

Nelson’s research on neglected children in Romanian orphanages suggests that early intervention might reverse damage from toxic stress. Orphans sent to live with nurturing foster families before age 2 had imaging scans several years later showing their brains looked similar to those of kids who were never institutionalized. By contrast, children sent to foster care at later ages had less gray matter and their brains looked more like those of children still in orphanages.

Toxic stress is not the same as post-traumatic stress disorder. PTSD is a distinct mental condition that can result from an extremely traumatic event, including combat, violence or sexual abuse. Experts say it can occur in adults and children who live with persistent toxic stress, including children in war-torn countries, urban kids who’ve been shot or live in violence-plagued neighborhoods, and those who have been physically or sexually abused.

The toxic stress theory has become mainstream, but there are skeptics, including Tulane University psychiatrist Dr. Michael Scheeringa, an expert in childhood PTSD. Scheeringa says studies supporting the idea are weak, based mostly on observations, without evidence of how the brain looked before the trauma.

The American Academy of Pediatrics supports the theory and in 2012 issued recommendations urging pediatricians to educate parents and the public about the long-term consequences of toxic stress and to push for new policies and treatments to prevent it or reduce its effects.

In a 2016 policy noting a link between poverty and toxic stress, the academy urged pediatricians to routinely screen families for poverty and to help those affected find food pantries, homeless shelters and other resources.

Recent studies suggest that severe stress changes the body’s metabolism and contributes to internal inflammation, which can raise risk for developing diabetes and heart disease.

“The science of how poverty actually gets under kids’ skin and impacts a child has really been exploding,” said Dr. Benard Dreyer, a former president of the academy.

Some pediatricians and schools routinely screen children and families for toxic stress, but it is not universal, said John Fairbank, co-director of the National Center for Child Traumatic Stress. “That’s certainly an aspiration. It would be a big step forward,” said Fairbank, a Duke University psychiatry professor.

Much of the recent interest stems from landmark U.S. government-led research published in 1998 called the Adverse Childhood Experiences study. It found that adults exposed to neglect, poverty, violence, substance abuse, parents’ mental illness and other domestic dysfunction were more likely than others to have heart problems, diabetes, depression and asthma.

A follow-up 2009 study found that adults with six or more adverse childhood experiences died nearly 20 years earlier than those with none.

Some children seem resistant to effects from toxic stress. Harvard’s Nelson works with a research network based at Harvard’s Center on the Developing Child that is seeking to find telltale biomarkers in kids who are affected — in saliva, blood or hair —that could perhaps be targets for drugs or other treatment to prevent or reduce stress-related damage.

That research is promising but results are likely years off, says Dr. Jack Shonkoff, the center’s director.

Alvin and Natalie Clarke brought their young grandchildren into their Cass City, Michigan home after their parents jailed on drug charges. The 6-year-old grandson hits, yells, breaks toys, misbehaves in school. His 4-year-old sister used to have nightmares and recoil in fear when her baby doll was left alone on the floor — signs her therapists say suggest memories of neglect.

The Clarkes had never heard the term “toxic stress” when they were granted guardianship in 2015. Now it’s a frequent topic in a support group they’ve formed for other grandparent-guardians.

Their grandson’s therapists say he has PTSD and behavior problems likely stemming from toxic stress. Around strangers he’s sometimes quiet and polite but the Clarkes say he has frequent tantrums at home and school and threatens his sister. He gets frightened at night and worries people are coming to hurt him, Natalie Clarke said.

Weekly sessions with a trauma-focused therapist have led to small improvements in the boy. The Clarkes say he needs more help but that treatment is costly and his school isn’t equipped to offer it.

The little girl has flourished with help from Early Head Start behavior specialists who have worked with her and the Clarkes at home and school.

“Thank God she doesn’t remember much of it,” Natalie Clarke said. “She’s a happy, loving little girl now.


Read the full article here. Source: https://nypost.com/2017/07/12/a-stressed-out-childhood-could-seriously-ruin-your-kids-brain/


By The Mladenoff Clinic of Arizona Team July 16, 2025
Let's take a deep dive into signs of nutrient deficiency you should never ignore. Cracked Lips - > B2 Deficiency Riboflavin (vitamin B2) deficiency, also known as a riboflavinosis, can cause a variety of symptoms, including skin disorders, mouth sores, and vision problems. It's often associated with other nutritional deficiencies and can be particularly risky during pregnancy. Treatment typically involves riboflavin supplementation and addressing any underlying conditions contributing to the deficiency. Signs and Symptoms Skin: Dermatitis, including red, scaly patches, especially around the mouth, nose, ears, and genitals. Cracks and fissures at the corners of the mouth (angular cheilitis) and on the lips (cheilosis). Mouth: Soreness, inflammation, and a magenta-colored tongue. Eyes: Itchy, red, and watery eyes, light sensitivity (photophobia), and blurred vision. In severe cases, it can contribute to cataracts. General Fatigue, anemia (especially in severe cases), and possibly depression. Some studies also suggest a link to migraines and peripheral neuropathy. Reproductive: Riboflavin deficiency during pregnancy can potentially lead to fetal birth defects and increase the risk of preeclampsia. Causes Inadequate dietary intake: Especially in populations with limited access to riboflavin-rich foods like dairy, meat, and eggs. Malabsorption: Conditions like celiac disease or inflammatory bowel disease can impair riboflavin absorption. Increased needs: Pregnancy, lactation, and intense exercise can increase riboflavin requirements. Bleeding Gums - > Vitamin C Deficiency Vitamin C deficiency, if severe and prolonged, can lead to a disease called scurvy. Scurvy is characterized by symptoms like fatigue, anemia, bleeding gums, poor wound healing, and skin problems. While scurvy is rare in the United States, it can affect older adults with poor nutrition. Symptoms Early symptoms: Fatigue, weakness, irritability, weight loss, and vague muscle and joint aches. Scurvy symptoms (develop after months of deficiency): Bleeding under the skin (especially around hair follicles and as bruises), swollen and bleeding gums, loose teeth, dry and brittle hair, dry and rough skin, fluid accumulation in the legs, and anemia. Infants: May exhibit irritability, pain upon movement, loss of appetite, impaired bone growth, and bleeding or anemia. Causes Insufficient dietary intake: Not eating enough fruits and vegetables, which are rich in vitamin C. Increased need: Certain conditions like smoking, drug or alcohol abuse, pregnancy, and breastfeeding can increase the body's need for vitamin C. Absorption issues: Problems with the gastrointestinal tract can hinder vitamin C absorption. Hair Loss - > Zinc Deficiency Zinc deficiency occurs when the body doesn't get enough zinc, a vital mineral. This can lead to a range of symptoms, including impaired immune function, slow wound healing, hair loss, and skin problems. In severe cases, it can also affect growth, sexual development, and cognitive function. Symptoms Impaired Immune Function: Zinc is crucial for a healthy immune system, and deficiency can increase susceptibility to infections. Delayed Wound Healing: Zinc plays a role in cell growth and repair, so a deficiency can slow down the healing of wounds. Skin Problems: Skin rashes, eczema-like lesions, and dry, flaky skin can be signs of zinc deficiency. Hair Loss: Zinc deficiency can contribute to hair loss or thinning. Digestive Issues: Diarrhea, especially in infants, is a common symptom. Loss of Appetite and Weight Loss: Zinc deficiency can reduce appetite and contribute to weight loss. Changes in Taste and Smell: A reduced ability to taste and smell can be a sign of zinc deficiency. Growth Retardation: In children, zinc deficiency can hinder growth and development. Cognitive Impairment: Zinc is important for brain function, and deficiency can affect alertness, memory, and learning. Eye Problems: In severe cases, zinc deficiency can affect vision, including night blindness. Causes Inadequate Dietary Intake: Not eating enough zinc-rich foods can lead to deficiency, particularly in people with restrictive diets or limited access to nutritious food. Malabsorption Issues: Certain medical conditions, such as Crohn's disease or celiac disease, can interfere with zinc absorption. Increased Excretion: Conditions like diarrhea or kidney disease can increase zinc excretion, leading to deficiency. Increased Needs: Pregnancy, breastfeeding, and periods of rapid growth can increase the body's zinc requirements. Alcohol Abuse: Excessive alcohol consumption can impair zinc absorption and increase excretion. Night Blindness - > Vitamin A Deficiency Vitamin A deficiency occurs when the body doesn't get enough vitamin A, a fat-soluble vitamin essential for vision, immune function, and cell growth. It's a global health concern, particularly in developing countries, and can lead to vision problems, including night blindness and, in severe cases, blindness. Causes Dietary deficiency: Inadequate intake of vitamin A-rich foods is the primary cause, especially in regions where rice, which lacks vitamin A, is a staple food. Malabsorption: Conditions like cystic fibrosis, celiac disease, or certain pancreatic disorders can hinder the body's ability to absorb vitamin A. Liver disorders: The liver stores vitamin A, so liver issues can impair the body's ability to utilize it. Other conditions: Iron or zinc deficiency can also impact vitamin A uptake. Symptoms Night blindness: Difficulty seeing in low light is often the first noticeable symptom. Xerophthalmia: Dryness of the conjunctiva (white part of the eye) and cornea, potentially leading to corneal ulcers and blindness. Impaired immune function: Vitamin A is crucial for a healthy immune system, and deficiency can increase susceptibility to infections. Growth problems: Vitamin A deficiency can hinder growth and development, especially in children. Muscle Cramps - > Magnesium Deficiency Magnesium deficiency, also known as hypomagnesemia, occurs when the body has low levels of magnesium. Symptoms can range from mild, like fatigue and muscle cramps, to severe, such as seizures or abnormal heart rhythms. It's important to address magnesium deficiency promptly as it can lead to various health complications. Common Symptoms Fatigue and Weakness: Feeling unusually tired or weak. Muscle Problems: Muscle cramps, spasms, and twitching. Loss of Appetite: Reduced desire to eat. Nausea and Vomiting: Feeling sick to the stomach and throwing up. Numbness and Tingling: Pins and needles sensations, particularly in the limbs. Abnormal Heart Rhythms: Irregular heartbeat. Headaches: Including migraines. Personality Changes: Irritability, anxiety, or confusion. Causes Poor Dietary Intake: Not consuming enough magnesium-rich foods. Gastrointestinal Issues: Conditions like Crohn's disease or celiac disease can impair magnesium absorption. Excessive Alcohol Consumption: Alcohol can interfere with magnesium absorption and increase excretion. Certain Medications: Some medications can deplete magnesium levels. Kidney Problems: Impaired kidney function can affect magnesium levels. Ice Cravings - > Iron Deficiency Iron deficiency, particularly in the form of iron deficiency anemia (IDA), is associated with sleep disturbances like insomnia, shorter sleep duration, and restless sleep. Symptoms Being pale or having yellow "sallow" skin. Unexplained fatigue or lack of energy. Shortness of breath or chest pain, especially with activity. Insomnia and sleep disturbances: Research indicates a link between anemia and insomnia, with some studies showing a higher risk of insomnia in individuals with IDA. Anemia can also lead to other sleep problems, such as restless legs syndrome (RLS). Reduced oxygen flow: Iron deficiency can affect oxygen delivery to the brain, potentially leading to sleep disturbances. Increased heart rate: The body may compensate for reduced oxygen by increasing heart rate, which can make it harder to fall asleep. Anxiety and neurotransmitter imbalances: Low iron levels can contribute to anxiety, which can disrupt sleep. Additionally, iron is involved in the production of neurotransmitters like dopamine, serotonin, and melatonin, which play crucial roles in sleep regulation. Restless legs syndrome: Iron deficiency is a known risk factor for RLS, a condition characterized by an irresistible urge to move the legs, often accompanied by uncomfortable sensations. Sleep alterations in infants: Studies have also found that early IDA in infancy is associated with long-lasting alterations in sleep patterns, such as changes in REM sleep duration and timing, even after iron treatment. Fatigue - > B12 Deficiency Vitamin B12 deficiency can lead to a range of health problems, including anemia, fatigue, nerve damage, and neurological issues. It's crucial to recognize the symptoms and seek medical advice for proper diagnosis and treatment. Symptoms General: Fatigue, weakness, pale or yellow skin, headaches. Neurological: Numbness or tingling in hands and feet, muscle weakness, problems with balance and coordination, vision problems, memory problems, confusion, depression, and irritability. Gastrointestinal: Digestive issues, loss of appetite, a smooth, sore, and inflamed tongue (glossitis). Causes Dietary: Insufficient intake of B12-rich foods (primarily found in animal products). This is especially relevant for vegetarians and vegans. Absorption Issues: Conditions like pernicious anemia (where the body can't absorb B12), celiac disease, Crohn's disease, or after weight loss surgery can hinder B12 absorption. Dry Skin - > Omega-3 Deficiency Omega-3 deficiency can lead to various health issues, including dry skin, joint pain, mood swings, and fatigue. Insufficient intake of these essential fatty acids, found in foods like fish, flaxseeds, and walnuts, can be a contributing factor. Addressing this deficiency can involve dietary changes and, in some cases, supplementation. Signs and Symptoms Skin Issues: Dry, rough skin, eczema, and increased sensitivity. Joint Pain: Omega-3s have anti-inflammatory properties, and deficiency can exacerbate joint pain and stiffness, according to NativePath. Mood Changes: Deficiency can impact mood, potentially leading to depression, anxiety, and irritability, according to Progressive Medical Center. Cognitive Function: Omega-3s are important for brain health. Deficiency can lead to brain fog, poor memory, and difficulty concentrating, says Zooki. Other Symptoms: Dry eyes, fatigue, increased thirst, and potential cardiovascular issues can also be linked to omega-3 deficiency. Hair and Nails: Brittle hair and nails can be a sign of omega-3 deficiency, as these fatty acids contribute to hair and nail health. Depression - > Vitamin D Deficiency Vitamin D deficiency occurs when the body doesn't have enough vitamin D, which is crucial for bone health, calcium absorption, and various other bodily functions. It can lead to a range of health problems, including bone pain, muscle weakness, and increased risk of fractures, especially in children and older adults. Several factors can contribute to deficiency, such as limited sun exposure, dietary inadequacies, and certain health conditions. Causes Insufficient Sun Exposure: Sunlight is the primary source of vitamin D for most people, as the skin produces it when exposed to UVB radiation. Factors like geographic location (especially during winter months), limited time outdoors, and using sunscreen can reduce vitamin D synthesis. Dietary Deficiency: Very few foods naturally contain vitamin D. While some foods like fatty fish, egg yolks, and fortified products (like milk and cereal) can help, they may not provide sufficient amounts for everyone. Malabsorption Issues: Certain conditions like Crohn's disease, celiac disease, and cystic fibrosis can hinder the body's ability to absorb vitamin D from food. Certain Medications: Some medications, including certain anticonvulsants and those used to treat HIV/AIDS, can interfere with vitamin D metabolism and absorption. Obesity: Individuals with a BMI over 30 may have lower vitamin D levels due to the vitamin being sequestered in body fat, making it less available for use. Darker Skin Tone: People with darker skin pigmentation produce less vitamin D in response to sunlight than those with lighter skin. Symptoms Bone Pain and Weakness: Vitamin D is essential for calcium absorption, which is needed for strong bones. Deficiency can lead to bone pain, especially in the back and hips, and can increase the risk of fractures. Muscle Weakness and Pain: Vitamin D receptors are present in muscles, and deficiency can lead to muscle weakness, fatigue, and increased risk of falls. Rickets (in children): In children, vitamin D deficiency can cause rickets, a condition where bones become soft and weak, leading to skeletal deformities, particularly bowed legs. Osteomalacia (in adults): In adults, deficiency can cause osteomalacia, which is a softening of the bones, leading to bone pain, muscle weakness, and increased risk of fractures. Fatigue and Mood Changes: Some individuals with vitamin D deficiency may experience fatigue, depression, and other mood changes. Pale Skin - > Iron or B12 Deficiency Frequent Infections - > Zinc or Vitamin C Deficiency Tingling/Numbness - > B12 Deficiency Bloating after meals - > Low Stomach Acid Brain Fog - > Choline Deficiency Restless Legs - > Iron or Magnesium Deficiency Schedule an appointment with Dr. Diana to address your symptoms and get to the root cause of your health issues. Call or Text 1 (602) 524-0222.
By The Mladenoff Clinic of Arizona Team June 2, 2025
One or more of these three bodily systems may be unbalanced without you even knowing it. Many health conditions can have knock-on effects in other areas (similar to how diabetes makes you more susceptible to periodontal disease). So be sure to have regular chiropractic treatments if you and your doctor think they could help avoid or manage any health problems.
By The Mladenoff Clinic of Arizona Team May 10, 2025
From enhanced immune function to reduced inflammation, increased energy levels, anti-aging effects, and relief from chronic pain, the positive effects of regular footbath sessions are abundant. By supporting the body's natural detoxification processes, this therapy aids in the removal of toxins, heavy metals, and other harmful substances, leading to improved overall health and well-being.
By The Mladenoff Clinic of Arizona Team March 7, 2025
As parents, we all want what’s best for our kids. We want them to do well in school, have a healthy social life, and grow up to be the best adult they can be. We do our best to love them, teach them, and keep them healthy, but what happens when our best efforts simply aren’t enough? This month's blog post dives into the positive benefits of a wellness plan that includes chiropractic care and more.
By The Mladenoff Clinic of Arizona Team February 5, 2025
Ron and Deb sat down with returning guest Dr. Mladenoff, a leading expert in concussion care, to discuss his new book which delves into the intricacies of diagnosing, treating, and understanding this serious health issue. Dr. Mladenoff shares personal experiences with concussions, both within his family and professionally, highlighting the physical, emotional, and long-term cognitive effects.
By The Mladenoff Clinic of Arizona Team January 6, 2025
Each time a chiropractor adjusts someone’s spine, we replace the negative information that is flooding the brain with positive information. This recalibrates the brain to help stop the release of chronic stress hormones and allows overall health and healing to occur. Every time a person receives a chiropractic adjustment, it positively affects the brain and nervous system. This positive effect on the brain promotes a state of ease and well-being within the body.
Show More